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Insuficiência Hepática - Em voluntários com cirrose hepática (classe A e B de Child-Pugh) o clearance da sildenafila se mostrou reduzido, resultando em um aumento da ASC (85%) e da Cmáx (47%), quando comparado com indivíduos de idade semelhante, sem insuficiência hepática (vide item 8! “Pravilnu dijagnozu može postaviti jedino doktor! Colestipol reduces plasma levels of atorvastatin, but lipid-lowering effects may be greater than when either drug is given alone.

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Each study consisted of two six-week treatment periods separated by a two-week washout period! Specifically, serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome.
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